Abstract

Case Report

Successful management of disseminated Fusarium infection in a patient with acute myeloid leukemia

AlShammasi S, AlNujaidi D, Bakhit K, Algarni A and AlAnazi KA*

Published: 17 September, 2018 | Volume 2 - Issue 1 | Pages: 015-020

Background: Invasive fungal infections cause significant morbidity and mortality in patients with hematologic malignancies and in recipients of hematopoietic stem cell transplantation.

Case: We report a patient with relapsed acute myeloid leukemia who developed disseminated Fusarium infection during the neutropenic period following the salvage cycle of chemotherapy given at King Fahad specialist Hospital in Dammam, Saudi Arabia. The invasive fungal infection was successfully managed with a combination of voriconazole and liposomal amphotericin-B.

Discussion: Fusarium species can cause invasive infections that may become disseminated and life-threatening in patients with acute myeloid leukemia.

Conclusion: Combined antifungal therapy and recovery of neutrophil count are essential to control invasive Fusarium infections

Read Full Article HTML DOI: 10.29328/journal.jhcr.1001007 Cite this Article Read Full Article PDF

Keywords:

Acute myeloid leukemia; Disseminated Fusarium infection; Febrile neutropenia; Combined antifungal therapy

References

  1. Garnica M, da Cunha MO,Portugal R, Maiolino A,Colombo AL,et al. Risk factors for invasive fusariosis in patients with acute myeloid leukemia and in hematopoietic cell transplant recipients. Clin Infect Dis. 2015; 60: 875-880. Ref.: https://goo.gl/4ZgKKE
  2. De Pinho DB, Fernandes LL, Carvalho Barreiros Mda G, Quintella LP, Sodré CT, et al. Disseminated fusariosis in a bone marrow transplant patient. J Clin Aesthet Dermatol. 2012; 5: 40-42. Ref.: https://goo.gl/jVtmkK
  3. Tang JL, Kung HC, Lei WC, Yao M, Wu UI, et al. High incidences of iInvasive fungal infections in acute myeloid leukemia patients receiving induction chemotherapy without systemic antifungal prophylaxis: a prospective observational study in Taiwan. PLoS One. 2015; 10: e0128410. Ref.: https://goo.gl/j2aXk7
  4. Bose P, Parekh HD, Holter JL, Greenfield RA. Disseminated fusariosis occurring in two patients despite posaconazole prophylaxis. J Clin Microbiol. 2011; 49: 1674-1675. Ref.: https://goo.gl/7qMhk9
  5. Uludokumacı S, Balkan Iİ, Mete B, Ozaras R, Saltoğlu N, et al. Ecthyma gangrenosum-like lesions in a febrile neutropenic patient with simultaneous pseudomonas sepsis and disseminated fusariosis. Turk J Haematol. 2013; 30: 321-324. Ref.: https://goo.gl/xYs5Bu
  6. Sheela S, Ito S, Strich JR, Manion M, Montemayor-Garcia C, et al. Successful salvage chemotherapy and allogeneic transplantation of an acute myeloid leukemia patient with disseminated Fusarium solani infection. Leuk Res Rep. 2017; 8: 4-6. Ref.: https://goo.gl/hhHgyc
  7. Dony A, Perpoint T, Ducastelle S, Ferry T. Disseminated fusariosis with immune reconstitution syndrome and cracking mycotic aortic aneurysm in a 55-year-old patient with acute myeloid leukaemia. BMJ Case Rep. 2013; 2013. bcr2013201050. Ref.: https://goo.gl/jziSxt
  8. Bourgeois GP, Cafardi JA, Sellheyer K, Andea AA. Disseminated Fusarium infection originating from paronychia in a neutropenic patient: a case report and review of the literature. Cutis. 2010; 85: 191-194. Ref.: https://goo.gl/TC7qpY
  9. Efe İris N, Güvenç S, Özçelik T, Demirel A, Koçulu S, et al. Successful treatment of disseminated fusariosis with the combination of voriconazole and liposomal amphotericin B. Turk J Haematol. 2016; 33: 363-364. Ref.: https://goo.gl/ERqDN9
  10. Al-Hatmi AM, Hagen F, Menken SB, Meis JF, de Hoog GS. Global molecular epidemiology and genetic diversity of Fusarium, a significant emerging group of human opportunists from 1958 to 2015. Emerg Microbes Infect. 2016; 5: e124. Ref.: https://goo.gl/MrL1ug
  11. Nucci M, Anaissie E. Fusarium infections in immunocompromised patients. Clin Microbiol Rev. 2007; 20: 695-704. Ref.: https://goo.gl/YZKZd4
  12. Nelson PE, Dignani MC, Anaissie EJ. Taxonomy, biology, and clinical aspects of Fusarium species. Clin Microbiol Rev. 1994; 7: 479-504. Ref.: https://goo.gl/LjQrLG
  13. Binder U, Lass-Flörl C. Epidemiology of invasive fungal infections in the mediterranean area. Mediterr J Hematol Infect Dis. 2011; 3: e20110016. Ref.: https://goo.gl/fuBgaQ
  14. Nucci M, Anaisssie E. Treatment and prevention of Fusarium infection. Edited by: Kauffman CA. Up To Date 2018. Ref.: https://goo.gl/hAUHtg
  15. Varon AG, Nouér SA, Barreiros G, Trope BM, Akiti T, et al. Antimold prophylaxis may reduce the risk of Invasive fusariosis in hematologic patients with superficial skin lesions with positive culture for Fusarium. Antimicrob Agents Chemother. 2016; 60: 7290-7294. Ref.: https://goo.gl/oEYuV3
  16. Summerbell RC, Richardson SE, Kane J. Fusarium proliferatum as an agent of disseminated infection in an immunosuppressed patient. J Clin Microbiol. 1988; 26: 82-87. Ref.: https://goo.gl/Sk5UXw
  17. Kiehn TE, Nelson PE, Bernard EM, Edwards FF, Koziner B, et al. Catheter-associated fungemia caused by Fusarium chlamydosporum in a patient with lymphocytic lymphoma. J Clin Microbiol. 1985; 21: 501-504. Ref.: https://goo.gl/vRy51H
  18. Perini GF, Camargo LF, Lottenberg CL, Hamerschlak N. Disseminated fusariosis with endophthalmitis in a patient with hematologic malignancy. Einstein (Sao Paulo). 2013; 11: 545-546. Ref.: https://goo.gl/1YiyTH
  19. Latif AL, Harper, Macdonald I, Morrison A. Splenectomy as an effective debulking therapy for disseminated mould infection in acute myeloid leukaemia following adjuvant therapy with interferon gamma and liposomal amphotericin. Med Mycol Case Rep. 2012; 1: 82-84. Ref.: https://goo.gl/72y4My
  20. Lockwood MB, Crescencio JC. Adventitious sporulation in Fusarium: The yeast that were not. IDCases. 2015; 3: 5-7. Ref.: https://goo.gl/CLfytq
  21. Kah TA, Yong KC, Rahman RA. Disseminated fusariosis and endogenous fungal endophthalmitis in acute lymphoblastic leukemia following platelet transfusion possibly due to transfusion-related immunomodulation. BMC Ophthalmol. 2011; 11: 30. Ref.: https://goo.gl/GXt4Bp
  22. Tezcan G, Ozhak-Baysan B, Alastruey-Izquierdo A, Ogunc D, Ongut G, et al. Disseminated fusariosis caused by Fusarium verticillioides in an acute lymphoblastic leukemia patient after allogeneic hematopoietic stem cell transplantation. J Clin Microbiol. 2009; 47: 278-281. Ref.: https://goo.gl/sUTxBu
  23. Durand-Joly I, Alfandari S, Benchikh Z, Rodrigue M, Espinel-Ingroff A, et al. Successful outcome of disseminated Fusarium infection with skin localization treated with voriconazole and amphotericin B-lipid complex in a patient with acute leukemia. J Clin Microbiol. 2003; 41: 4898-900. Ref.: https://goo.gl/HQPVLS
  24. Liu YS, Wang NC, Ye RH, Kao WY. Disseminated Fusarium infection in a patient with acute lymphoblastic leukemia: A case report and review of the literature. Oncol Lett. 2014; 7: 334-336. Ref.: https://goo.gl/smCTuQ
  25. Austen B, McCarthy H, Wilkins B, Smith A, Duncombe A. Fatal disseminated fusarium infection in acute lymphoblastic leukaemia in complete remission. J Clin Pathol. 2001; 54: 488-490. Ref.: https://goo.gl/Eu8sBD
  26. Vagace JM, Sanz-Rodriguez C, Casado MS, Alonso N, Garcia-Dominguez M, et al. Resolution of disseminated fusariosis in a child with acute leukemia treated with combined antifungal therapy: a case report. BMC Infect Dis. 2007; 7: 40. Ref.: https://goo.gl/mVDrry
  27. Young NA, Kwon-Chung KJ, Kubota TT, Jennings AE, Fisher RI. Disseminated infection by Fusarium moniliforme during treatment for malignant lymphoma. J Clin Microbiol. 1978; 7: 589-594. Ref.: https://goo.gl/JzNFSX
  28. de Souza M, Matsuzawa T, Lyra L, Busso-Lopes AF, Gonoi T, et al. Fusarium napiforme systemic infection: case report with molecular characterization and antifungal susceptibility tests. Springerplus. 2014; 3: 492. Ref.: https://goo.gl/eYVkHH
  29. Esnakula AK, Summers I, Naab TJ. Fatal disseminated fusarium infection in a human immunodeficiency virus positive patient. Case Rep Infect Dis. 2013; 2013: 379320. Ref.: https://goo.gl/9cncX3
  30. Lortholary O, Obenga G, Biswas P, Caillot D, Chachaty E, et al. International retrospective analysis of 73 cases of invasive fusariosis treated with voriconazole. Antimicrob Agents Chemother.2010; 54: 4446-4450. Ref.: https://goo.gl/DvvsrA
  31. Muhammed M, Anagnostou T, Desalermos A, Kourkoumpetis TK, Carneiro HA, et al. Fusarium infection: report of 26 cases and review of 97 cases from the literature. Medicine (Baltimore). 2013; 92: 305-316. Ref.: https://goo.gl/Q9HyL7
  32. Carneiro HA, Coleman JJ, Restrepo A, Mylonakis E. Fusarium infection in lung transplant patients: report of 6 cases and review of the literature. Medicine (Baltimore). 2011; 90: 69-80. Ref.: https://goo.gl/adyUag
  33. Carlesse F, Amaral AC, Gonçalves SS, Xafranski H, Lee MM, et al. Outbreak of Fusarium oxysporum infections in children with cancer: an experience with 7 episodes of catheter-related fungemia. Antimicrob Resist Infect Control. 2017; 6: 93. Ref.: https://goo.gl/qrnM82
  34. Nucci M, Varon AG, Garnica M, Akiti T, Barreiros G, et al. Increased incidence of invasive fusariosis with cutaneous portal of entry, Brazil. Emerg Infect Dis. 2013; 19: 1567-1572. Ref.: https://goo.gl/UHKwjS
  35. Muhammed M, Coleman JJ, Carneiro HA, Mylonakis E. The challenge of managing fusariosis. Virulence. 2011; 2: 91-96. Ref.: https://goo.gl/UzK1tA
  36. Mousset S, Buchheidt D, Heinz W, Ruhnke M, Cornely OA, et al. Treatment of invasive fungal infections in cancer patients-updated recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO). Ann Hematol. 2014; 93: 13-32. Ref.: https://goo.gl/zgdS29
  37. Amirrajab N, Aliyali M, Mayahi S, Najafi N, Abdi R, et al. Co-infection of invasive pulmonary aspergillosis and cutaneous Fusarium infection in a patient with pyoderma gangrenosum. J Res Med Sci. 2015; 20: 199-203. Ref.: https://goo.gl/Qom7sL
  38. Moretti ML, Busso-Lopes AF, Tararam CA, Moraes R, Muraosa Y, et al. Airborne transmission of invasive fusariosis in patients with hematologic malignancies. PLoS One. 2018; 13: e0196426. Ref.: https://goo.gl/769WMa

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