Myeloma Presenting with Paraneoplastic Syndrome: Inflammatory-demyelinating Condition of the Central Nervous System
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Abstract
Multiple myeloma (MM) is a clonal plasma cell malignancy classically presenting with CRAB features: hypercalcaemia, renal impairment, anaemia and osteolytic bone disease. Paraneoplastic neurological manifestations are rare and poorly characterised, with evidence limited largely to isolated case reports. We describe an unusual case of MM presenting with recurrent inflammatory-demyelinating central nervous system (CNS) disease, demonstrating diagnostic complexity and responsiveness to anti-myeloma therapy.
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Copyright (c) 2026 Patel S, et al.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Dhillon Hirani, Luton and Dunstable University Hospital NHS Foundation Trust: Luton, England
SHO within the team who contributed to the manuscript
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