Performance Evaluation of Erba H7100 with Sysmex XN-1000

Abstract

Introduction: Accurate hematology analyzers are essential for the diagnosis and monitoring of hematological disorders. This study evaluates the analytical performance of the Erba H7100 against the established Sysmex XN-1000 to determine agreement, precision, and suitability for routine clinical use.
Methods: A total of 243 anonymized EDTA-anticoagulated patient samples were collected and processed within two hours. Of these, 200 samples were analyzed in parallel on both analyzers for direct method comparison, while the remaining samples were used for repeatability and precision assessments. Parameters evaluated included WBC, RBC, HGB, HCT, PLT, RET%, RET#, IG#, NRBC%, and differential counts. Statistical tools included Student’s t-test, Pearson correlation, linear regression, chi-square, and Bland–Altman analysis.
Results: Strong correlations (r ≥ 0.95) were observed for WBC, RBC, HGB, HCT, PLT, and RET%. Moderate correlations were observed for lymphocyte and monocyte counts, while IG#, Bas#, and RET# showed weaker correlations and some clinically relevant differences. Most parameters showed acceptable agreement for routine clinical use, though RET# and IG# require further optimization.
Conclusion: The Erba H7100 demonstrates analytical performance comparable to Sysmex XN-1000 for most routine hematology parameters. It is suitable for clinical implementation, with potential economic advantages. Parameters like RET#, IG# will require further refinement.